Hot Keys

Hot Keys are keyboard shortcuts for in game commands.

Map

W, A, S, D - Like many games these keys will move screen focus. Up, Left, Down, Right respectively. Holding Shift at the same time moves the focus faster.
Esc - brings up main menu.
1, 2, 3 - change game speed
Space - (un)pauses the game
Left Alt + S - screenshot mode, removes overlays from display

Skills

B, G, T - When dealing with Skills these keys will move the selected skill icon to the bottom of the listing (B), disable the skill (G), or shift the skill to the top (T)
N, Y - lower or raise the highlighted Skill by a single rank

Items, Objects and Buildings

B - When looking at the infocard for Objects, Buildings, this will bring up the blueprint for that thing so another can be built.
X - dismantle the thing.
C - Crate an Object
P - makes the Item a Priority (Emergency Boost), whether for Hauling, Repair, etc.
V - stops the thing being used.

Blueprints

X - Cancels a placed blueprint.
V - Turns off a blueprint so Clanfolk won't build the item but the plan remains on the map.
R - Most (but not all) Objects may be Rotated before placing the blueprint. The middle mouse button (if such exists) can have the same effect.